Psilocybin Laws in Colorado
Colorado voters passed Proposition 122 in November 2022, creating the most permissive psilocybin framework in the US. Adults 21+ have state-level personal-use protections, and Colorado's regulated natural medicine licensing system moved from applications into issued licenses and operating healing centers in 2025.
Two tracks: personal use and regulated services
Colorado's official materials separate DORA facilitator licensing from Department of Revenue business compliance. The state has personal-use protections, but commercial sales outside the regulated framework remain prohibited.
Check DORA license status for facilitators and state/local compliance before trusting a healing-center claim.
Personal adult use does not mean retail mushroom sales, delivery menus, or unlicensed paid services are lawful.
Facilitator licensing
Colorado DORA shows active facilitator licensing, continuing-education requirements, application data, and links to license lookup resources.
Open official source
No commercial sales
Colorado's Natural Medicine Division says commercial sale of psilocybin mushrooms remains prohibited, even inside the personal-use environment.
Open official sourceCurrent Legal Status
Legal Healing Centers + Personal Use Decriminalized
Colorado has a two-track system. Personal use: adults 21+ may possess, grow, and share (not sell) psilocybin for personal use under state law. Regulated services: licensed facilitators and licensed natural-medicine businesses operate under DORA, Department of Revenue, CDPHE, and local compliance rules.
Key Legislation
Proposition 122 (2022) — the Natural Medicine Health Act — decriminalized personal adult use and created the healing center framework. DORA oversees licensing. Denver was the first US city to decriminalize psilocybin at the municipal level (May 2019), two years before the state program.
Therapeutic Programs
Colorado's regulated service lane is active, but license status and local operating permission should be checked before relying on any provider claim. DORA licenses facilitators; the Department of Revenue Natural Medicine Division regulates businesses such as healing centers, cultivation, manufacturing, and testing.
Decriminalization
Personal adult possession, cultivation, and gifting (non-commercial) of psilocybin mushrooms is decriminalized statewide for adults 21+.
Clinical Trials
University of Colorado Boulder and COMPASS Pathways have conducted Colorado-based psilocybin research. Active studies underway — check ClinicalTrials.gov.
Advocacy Organizations
Natural Medicine Colorado, Healing Advocacy Fund, Colorado Healing Alliance, DORA (regulatory body).
Related Resources
Directory in Colorado
- Dreamscape — Source-Backed Shop / Company
- HCU Mushrooms — Source-Backed Shop / Company
- Lyman Support Centers — Source-Backed Shop / Company
- Sage Psychedelic Institute — Colorado Healing Center
- Ceremonia — Sacramental Church / Community
- Colorado Psychedelic Church / PACK Life — Sacramental Church
- Psilovibe Church — Sacramental Church / Community
- Center Origin — Colorado Healing Center
- ETC Hospitality Center — Colorado Healing Center
- Happy Rebel Healing — Colorado Healing Center
- SANCTUM — Colorado Healing Center
View all Colorado directory listings →
People in Colorado
- Teopixqui Dez — Founder & Spiritual Director, Colorado Psychedelic Church / PACK Life
- Lorey Bratten — Director, Colorado Natural Medicine Advisory Board
- Dr. Sue Sisley — Medical Researcher; Colorado Natural Medicine Advisory Board Member
- Dan Engle, M.D. — Psychiatrist; Psychedelic-Assisted Therapy Practitioner; Author
Societies & Organizations in Colorado
- Psychedelic Club of Denver (PCoD) — Community Society
- Colorado Mycological Society — Mycology Club
- The Nowak Society — Professional Network
- Colorado Psychedelic Society — Community Group
- Colorado Veterans Natural Medicine Alliance — Veterans Advocacy
See how Colorado compares to neighboring states and find therapy options for residents: